THE CHANCE

    I have seen progress in medicine and many of the diseases which had no specific treatment in past ,now has some and we are making progress. But sometimes when a new drug comes to market , there are people who 'demand' it be used and there are some physicians who use it. I feel that sometimes there is some  overuse. Recently a drug came in market for COPD -chronic obstructive lung disease, which is relatively old drug and approved for asthma and  some other conditions in past for last few years , and now approved for COPD. The drug representatives were in my office the other day and were asking me how come I am not using it yet . My answer was I need to find appropriate patient for the use . But your collogues are using a lot  ,was the comment. My answer was may be they have more appropriate patient . But that brings me to the patient for today.  

  I had seen this male patient - may be  years old 3-4 years ago . He had chronic cough and so we did the work up . It looked like  that he may have some allergies and some mild asthma. I did some investigations and did treat his asthma , which was seen on his breathing test , but he had some reduction in his diffusion capacity. The oxygen and carbon dioxide 'diffuse' across the lungs  or air sacks and when we m= checked that as part of breathing test , we found out that that was reduced . So I did CT scan and he had some  ILD - Interstitial  Lung Disease. - something that can cause fibrosis - scarring in lungs and also can cause cough and shortness of breath. ]This also can be seen with allergies and also can be related to certain medications and then some have no known cause and so we call it Idiopathic . This last one has poor prognosis . 

  I did the work up and he had no known allergies  and no work history and the bronchoscopy did not show any infection. So we talked on the diagnosis and some treatment . The drugs that were approved in may be are costly , do not reverse or cure the disease , but just reduce the rate of decline . In my personal opinion, which I had expressed in an interview when the drug came out in USA is that we do not have clear cut knowledge as which patient will get worse and which will not. So, it is very difficult to decide - o tests that can tell us on the 'chance' of worsening .So I do repeat tests in 4-6 months and anybody who worsens we start the drug . If they are very sick and have need for the oxygen ,then I start then quickly. 

  This patient had family history of such lung problem and so he was to go to John Hopkins for some research. We watched him . He did not get worse , but he was stable for a year or more and then I continued to do follow up. He had also gone to Hopkins and they did some blood tests on genetics work up. He continued ton do follow up and the cough had subsided and then the diffusion got better and after 3 years or more his last CT scan shows minimal scarring - the CT scan is significantly improved. 

   He does not need medications and if I had started him on medications , he would have been counted as 'success story'. The drug company has data that shows that when medications were started 'early ' they did better , but how many of them could have not had progression of the disease even if they were not on drug? This is impossible to be determined as we cannot and will not hold the drug if we have the worsening disease.

   My be in future we will have some tests - markers that will tell us as who is going to get worse and we can start drug quickly, and not overuse it.   

DOUBLING TIME AND VARIATION

    I see many patients who have abnormal CT scan and the scan shows nodule , we do tests to find out as to the cause of the nodules . Just for the sake of knowledge, the solid nodules , and nodules with speculations are more likely to be cancerous than ground glass  nodule which is like haziness. There are many things taken in to account when we think of the nodules and they may be male- female, size of the nodules and characters of the nodule , smoking history, age , upper lobe -lower lobe etc. But with smaller size we tend to do follow up of scans . How often one should do scans is based on possibility of the nodule being cancer and growth pattern and how our science can detect it at it's earliest . The nodules which are very small are impossible to be biopsied. Her we think of doubling time of cancer - how long does it take for the nodule to become double it's size in volume. The fast growing cancer will double in 45 days and slow growing will double in more than 1 year , but many will do size change which can be detected , in 90-120 days . This brings me to the story for the day. 

   I have seen this patient and his wife for last 10 years or so. Bothe of them were smoker and had COPD -emphysema and they were on medications , needed oxygen at times and steroids . Also needed hospitalization. But continued to smoke . He had a ct scan of chest may be 2and half years ago and gthat showed a nodule . The nodule was small and so we talked about the possibility of cancer as he has been smoker and he did not want much testing and ,so, we did do follow up of the scan and he agreed . The new scan was done and that did not show much change . Then we did do another follow up and that showed that the nodule had grown and now it was over an centimeter . So I asked him to do PET scan . He was not very keen on doing PET scan, but finally he did it. The nodule did pick up and so it was now more likely to be cancerous . He was not a good candidate for surgery as he needed oxygen and had poor reserve - based on breathing test to undergo surgery and resection. So I suggested doing radiation after doing a needle biopsy. He refused biopsy and did not want radiation, but wanted to just do follow up .I told him that if the nodule becomes too big - larger than an inch, short course f radiation will not be option and then he will need prolonged course of radiation. He still did not want radiation. So I have done few more scans and then nodule has grown by very small amount may be 2 mm - 25 mm make an inch . Almost 3 years have passed by since we detected the nodule first time. I am sure that he has a cancer , but it is growing at such low rate that he falls out side the 90-120 days rule. 

 So much for the doubling time discussion.